6/23/2023 0 Comments Sigma aldrich sds![]() ![]() Disruption of BAF complex assembly affected the coregulation of YAP1 and β-catenin, indicating that this chromatin remodeling complex plays a crucial role for interdependent YAP1 and β-catenin activation in synovial sarcoma cells. ![]() Coimmunoprecipitation experiments detected nuclear interactions between YAP1, β-catenin, and the SS18-SSX fusion protein, the latter being an integral part of the BAF complex. These analyses showed the highest cooperative effect with overexpression of YAP1 in combination with β-catenin. In vitro, small-molecule inhibitor treatment, RNAi-mediated knockdown, and vector-based overexpression assays demonstrated that YAP1, TAZ, and β-catenin transcriptional activity is not only stimulated by the SS18-SSX fusion protein, but that they also mutually enhance each other's activation. In a large cohort of synovial sarcoma tissue specimens, IHC analyses revealed a substantial subset of synovial sarcoma with concurrent nuclear accumulation of YAP1/TAZ and β-catenin. ![]() Because previous functional analyses revealed a connection between SS18-SSX and the activity of the transcriptional coregulators YAP1/TAZ and β-catenin, respectively, this study examined a potential interdependence between these essential effector proteins in synovial sarcoma. Brij® 35 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. The resulting chimeric SS18-SSX fusion protein drives synovial sarcoma pathogenesis by integrating into the BAF complex and dysregulating gene transcription. 5 methoxyl basis CAS Number: Synonyms: Methyl cellulose find Sigma-Aldrich-64605 MSDS, related peer-reviewed papers, technical documents. Synovial sarcoma, a rare malignant soft tissue tumor, is characterized by a specific chromosomal translocation t(X 18). LOUIS MO 63103 UNITED STATES Telephone : +1 314 771-5765 Fax : +1 800 325-5052 1. ![]()
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